DNA TYPING OF INHERITED DEFICIENCY OF CAPRINE MUCOPOLYSACCHARIDOSIS IIID
D. Y. Lin, Y. C. Huang, G. Lu and H. L. Chang
Taiwan Livestock Research Institute, Council of Agriculture
Caprine Mucopolysaccharidosis IIID, or N-acetylglucosamine 6-sulfatase deficiency (G6S), is a recessive inherited disorder in goat. To explore the impact of G6S on goat industry, a total of 61 samples collected from private goat farm of eastern Taiwan in 1998, were tested. Samples represented Nubian (18 females and 2 males), Toggenburg (16 females and 4 males) and Taiwan native goat (20 females and 1 male). Five carrier goats were found in 20 Nubian with frequency being 25%. No carrier was found in Toggenburg or Taiwan native goat. Further screen were performed by 141 blood DNA samples from all Nubian goats’ of the farm in Aug. 2002. The frequency of carried was 15%(21/141) which explores risk of high frequency of G-6-S of Taiwan Nubians existed. No affected individual, homozygous recessive goat, was found in this trial. Nubian is one of the major resource goat breeds for meat production in Taiwan, and thus the corresponding frequency of G6S deserves to gain more attention.