第四十五卷(2016)
候選小公牛遺傳缺陷基因型分析
廖仁寶 陳若菁 李國華 陳志毅 賈玉祥 吳明哲
行政院農業委員會畜產試驗所
本研究目的在探討候選小公牛常見遺傳缺陷基因型頻率，包括牛淋巴球黏力缺失症、瓜胺酸 血症、單譜症、脊椎畸形複合症及短脊椎綜合症。本研究自全國種牛場收集 28 頭候選小公 牛血樣，經 DNA 萃取與 5 項遺傳缺陷基因型檢測後發現，所有候選小公牛除 BS 基因型 有雜合型外，其餘 4 項遺傳缺陷基因型皆屬正常型，而 BS 雜合型的頻率則高達 10.71%。 藉由篩除攜帶有不良遺傳缺陷基因的候選小公牛，將來可避免把此等公牛不良基因經由人工 授精而散布於乳牛族群中，造成產業之潛在損失。
關鍵語：遺傳缺陷、基因型、候選小公牛
Genotyping of genetic defects for young bull candidates
R. B. Liaw, J. C. Chen, K. H. Lee, J. Y. Chen, Y. S. Jea and M. C. Wu
Livestock Research Institute, Council of Agriculture, Executive Yuan
This study was conducted to genotype frequencies of bovine genetic defects, including Bovine Leukocyte Adhesion Deficiency (BLAD), Deficiency of Uridine Monophosphate Synthase (DUMPS), Citrullinemia (CITL), Complex Vertebral Malformation (CVM), and Brachyspina Syndrome (BS), for young bull candidates. A total of 28 blood samples of young bull candidates were obtained from breeding farms in Taiwan. The cattle DNA was extracted and tested for 5 genetic defects. The results showed that all the genotypes except BS were normal, and the BS carrier frequency was as high as 10.71%. Through eliminating those bulls with genetic defects the recessive lethal genes can be avoided transmitting to cattle population by AI with the semen produced from those defective bulls. Therefore, the potential financial loss due to genetic defects could be prevented for dairy industry.
Key Words: Genetic defect, Genotype, Young bull candidate
  
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